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Chemical structures of small molecules that suppress TGF-β1/ALK5 signaling. SJN2511 and SB431542 are selective ALK5 inhibitors. Losartan, a selective antagonist for AT1 can downregulate TGF-β/ALK5 signaling in both the periphery and the CNS. Abbreviations: ALK5, activin-like kinase 5; AT1, angiotensin II receptor type 1.
