Table 1.
Pregnancy endpoints following GW4064 treatment1.
| Virgin Vehicle | Virgin GW4064 | Pregnant Vehicle | Pregnant GW4064 | |
|---|---|---|---|---|
| Liver: Body weight | 0.0569±0.0019 | 0.0554±0.0017 | 0.0647±0.00070* | 0.0681±0.0010* |
| Resorptions | N/A | N/A | 1.00±0.36 | 0.667±0.33 |
| Estradiol (pg/mL) | 7.91±0.4 | 7.85±1.3 | 12.8±0.8* | 12.1±2.0 |
| Progesterone (ng/mL) | 3.70±1.0 | 2.68±0.6 | 28.0±1.8* | 20.3±3.2*‡ |
| Triglycerides (mg/dL) | 36.9±1.1 | 36.1±2.7 | 65.0±4.2* | 55.7±4.7* |
| Cholesterol (mg/dL) | 91.0±5.7 | 100.7±3.1 | 90.9±3.6 | 92.3±3.1 |
1
Body weights, liver weights and number of resorptions were recorded at the time of sacrifice. Total litter sizes ranged from 1 to 9 (mean 5.5). Circulating progesterone, estradiol, total bile acids, triglycerides and cholesterol were quantified for vehicle- and GW4064-treated mice on gestation day 14. Data are presented as mean ± SE (n=5–6).
Asterisks (*) represent statistically significant difference (p≤0.05) compared with vehicle-treated virgin mice. Double daggers (‡) represent statistically significant difference (p≤0.05) compared with vehicle-treated pregnant mice. N/A: not applicable.