Figure 10.
Efficacy of orally administered budesonide solution, budesonide PLGA nanoparticles and Eudragit S100-coated budesonide PLGA nanoparticles in various murine colitis models. (A) In vivo high resolution mini-endoscopy of mice intestines, (B) colitis scores after treatment with different budesonide formulations and untreated controls, and (C) combined colitis scores obtained from various murine colitis models. Eudragit S100-coated budesonide PLGA nanoparticles showed significantly higher efficacy (p < 0.001) than budesonide PLGA nanoparticles. Adapted from [197] with permission.