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Efficacy of orally delivered 100 mg/kg or 300 mg/kg redox nanoparticles (RNPo) and 35 mg/kg mesalamine (5-ASA) in a murine DSS-induced colitis model. Efficacy evaluated by measuring (A) disease activity index, (B) colon length, and (C) secretion of inflammatory cytokine IL-1β. Orally delivered RNPo at the dose of 300 mg/kg showed better efficacy than mesalamine at 35 mg/kg (p < 0.05). Adapted from reference [200] with permission.
