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. Author manuscript; available in PMC: 2017 Oct 28.
Published in final edited form as: J Control Release. 2016 Jun 9;240:504–526. doi: 10.1016/j.jconrel.2016.06.016

Figure 4.

Figure 4

Fluorescence microscopic z-scans of 200 nm fluorescent red polystyrene nanoparticles incubated with (a) Caco-2 monolayer, (b) Caco-2/M cell double culture, (c) Caco-2/HT29-MTX double culture, and (d) Caco-2/HT29-MTX/M cell triple culture. The arrows depict particle aggregates caught on the luminal side, and circles indicate nanoparticle uptake/penetration. The presence of mucus dramatically decreased nanoparticle uptake, while M cells facilitate nanoparticle translocation. Adapted from reference [111] with permission.