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. Author manuscript; available in PMC: 2017 Oct 28.
Published in final edited form as: J Control Release. 2016 Jun 9;240:504–526. doi: 10.1016/j.jconrel.2016.06.016

Table 1.

Pharmacokinetics of orally delivered Taxotere® and enteric microparticles containing docetaxel PLGA nanocaspules (both equivalent to 1.25 mg/kg of docetaxel) in minipigs (n=3). Enteric microparticles containing docetaxel PLGA nanocaspules showed significantly higher Cmax and AUC as compared to Taxotere® (p < 0.05). Adapted from reference [193] with permission

Oral Formulation Cmax (ng/mL) AUC (h.ng/mL) Clearance (L/h/kg)
Docetaxel solution 97.6 ± 221 797.7 ± 1141 4 ± 2.8
Enteric microparticles containing docetaxel PLGA nanocaspules 827.9 ± 558 7923.1 ± 5644 0.4 ± 0.5