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. Author manuscript; available in PMC: 2017 Oct 28.
Published in final edited form as: J Control Release. 2016 Jun 8;240:489–503. doi: 10.1016/j.jconrel.2016.06.012

Figure 1.

Figure 1

EMBASE® and MEDLINE® search results on drug delivery systems for co-delivering combination chemotherapy over the past fifteen years. According to systematic review from both EMBASE® and MEDLINE®, the earliest research on co-loading anticancer drug and chemosensitizing drug within the same drug carrier to enhance drug toxicity against P-gp overexpressing multidrug resistant cells were first reported by Liu et al, 1999, followed by Soma et al., 2000, Liu et al., 2003, and Wong et al. 2004; 2006 [27-31].