Table 1.
Baseline characteristics of sepsis patients with and without hypothermia during the first 24 h of admission
| Hypothermia | No hypothermia | P | |
|---|---|---|---|
| N = 186 | N = 339 | ||
| Demographics | |||
| Age, years, mean (SD) | 65.0 (13.8) | 61.1 (15.6) | 0.004 |
| Gender, male, n (%) | 114 (61.3) | 206 (60.8) | 0.94 |
| BMI, kg/m2, mean (SD) | 25.6 (5.7) | 26.7 (6.7) | 0 .04 |
| Comorbidities | |||
| Charlson score, median (IQR) | 5 (3–6) | 4 (2–6) | 0.01 |
| Cerebrovascular disease, n (%) | 28 (15.1) | 27 (8) | 0.01 |
| Chronic cardiovascular insufficiency, n (%) | 13 (7) | 7 (2.1) | 0.009 |
| Chronic renal insufficiency, n (%) | 26 (14) | 32 (9.4) | 0.15 |
| Congestive heart failure, n (%) | 8 (4.3) | 17 (5) | 0.84 |
| COPD, n (%) | 29 (15.6) | 61 (18) | 0.55 |
| Diabetes mellitus, n (%) | 42 (22.6) | 67 (19.8) | 0.51 |
| Hypertension, n (%) | 73 (39.2) | 87 (25.7) | 0.003 |
| Liver cirrhosis, n (%) | 7 (3.8) | 6 (1.8) | 0.23 |
| Peripheral vascular disease, n (%) | 25 (13.4) | 44 (13) | 0.90 |
| Admission | |||
| Admission type, medical, n (%) (%) | 163 (87.6) | 298 (87.9) | 0.55 |
| Admission origin, emergency department, n (%) (%) | 74 (39.8) | 99 (29.2) | 0.04 |
| medium care, n (%) | 26 (14) | 47 (13.9) | |
| ward, n (%) | 86 (46.2) | 193 (56.9) | |
| Site of infection | |||
| Pulmonary, n (%) | 79 (42.5) | 161 (47.5) | 0.28 |
| Abdominal, n (%) | 29 (15.6) | 65 (19.2) | 0.34 |
| Urinary tract, n (%) | 32 (17.2) | 33 (9.7) | 0.02 |
| Other, n (%) | 18 (9.7) | 44 (13) | 0.31 |
| Co-infection, n (%) | 28 (15.1) | 36 (10.6) | 0.15 |
| Severity of disease first 24 h | |||
| Mean temperature first 6 h, median (IQR) | 36.1 (35.4–37) | 37.2 (36.5–38) | <0.0001 |
| Mean temperature first 24 h, median (IQR) | 36.3 (35.8–36.9) | 37.3 (36.8–37.8) | <0.0001 |
| APACHE IV score, median (IQR)a | 82 (67–103) | 71 (58–86) | <0.0001 |
| SOFA score, median (IQR)b | 8 (5–10) | 7 (4–8) | <0.001 |
| Acute kidney injury, n (%) | 92 (49.5) | 118 (34.8) | 0.002 |
| Renal replacement therapy, n (%) | 32 (17.1) | 21 (6.2) | <0.001 |
| Acute lung injury, n (%) | 49 (26.3) | 99 (29.2) | 0.57 |
| Shock, n (%) | 74 (39.8) | 106 (31.3) | 0.06 |
| Clinical laboratory parameters first 24 h | |||
| WBC count max. (×10^9/L), median (IQR) | 16.1 (10.9–25.5) | 14.9 (10–19.2) | 0.02 |
| WBC count min. (×10^9/L), median (IQR) | 12.6 (7.1–19.1) | 12.2 (7.7–16.2) | 0.25 |
| Platelets min. (×10^9/L), median (IQR) | 189 (120–264) | 199 (131–283) | 0.27 |
| Lactate max. (mmol/L), median (IQR) | 3.2 (1.6–6.5) | 2.5 (1.6–4.1) | 0.009 |
| Prothrombin time max. (s), median (IQR) | 16.5 (14.1–20.7) | 15 (12.6–18.2) | 0.0001 |
| Creatinin max. (μmol/L), median (IQR) | 121 (80–209) | 97 (68–162) | <0.001 |
| C-reactive protein (mg/L), median (IQR) | 146 (82–258) | 174 (98–263) | 0.25 |
aTemperature not included in score. bCentral nervous system not included in score due to large number of sedated patients. APACHE Acute Physiology And Chronic Health Evaluation, COPD chronic obstructive pulmonary disease, IQR interquartile range, SD standard deviation, SOFA Sequential Organ Failure Assessment, WBC white blood cell