. 2016 Oct 1;29(8):464–470. doi: 10.1089/vim.2016.0057

Table 2.

The Ratio (Median %) of HLA-DR⁺ and CCR5⁺ Lymphocyte Subsets to the Parent Cell Population Among PWID

Cell populations	HIV+HBV+HCV+ (n = 35)	HIV−HBV+HCV+ (n = 18)	HIV−HBV−HCV+ (n = 17)	Triple negative (n = 11)	p^a	p^b	p^c
HLA-DR⁺ lymphocyte subsets
CD4⁺ HLA-DR⁺	12.0 (6.6–19.2)	4.9 (3.6–5.6)	5.5 (4.2–6.5)	5.4 (4.1–8.7)	<0.001	<0.001	0.011
T_CM HLA-DR⁺	13.0 (8.9–19.5)	4.0 (3.5–4.7)	5.2 (3.8–5.5)	4.9 (3.7–6.0)	<0.001	<0.001	<0.001
T_EM HLA-DR⁺	38.6 (30.2–50.5)	18.0 (13.2–20.6)	17.5 (14.9–23.5)	23.2 (21.0–25.9)	<0.001	<0.001	0.050
CD8⁺ HLA-DR⁺	45.8 (37.4–53.1)	13.6 (8.5–18.5)	15.6 (13.0–22.0)	23.9 (15.2–27.9)	<0.001	<0.001	<0.001
T_N HLA-DR⁺	4.0 (2.9–7.6)	2.3 (1.8–3.7)	2.3 (1.7–3.9)	2.8 (1.1–3.8)	0.017	0.017	0.076
T_CM HLA-DR⁺	33.9 (19.7–47.2)	7.6 (6.4–8.9)	10.3 (6.9–13.6)	9.5 (5.3–12.9)	<0.001	<0.001	<0.001
T_EM HLA-DR⁺	54.1 (47.6–62.2)	23.0 (12.6–31.1)	29.1 (20.3–36.2)	31.3 (23.5–38.6)	<0.001	<0.001	<0.001
T_TEMRA HLA-DR⁺	37.2 (27.2–46.0)	21.2 (9.2–26.1)	20.9 (14.7–26.1)	30.8 (18.9–42.3)	<0.001	<0.001	0.718
CCR5⁺ lymphocyte subsets
CD4⁺ T_EM CCR5⁺	7.0 (2.3–9.3)	7.6 (4.1–10.0)	9.6 (6.0–12.0)	10.9 (8.2–12.6)	0.987	0.239	0.026
CD8⁺ T_N CCR5⁺	1.5 (0.5–3.2)	0.5 (0.3–1.4)	0.3 (0.1–0.4)	0.7 (0.1–1.0)	0.055	<0.001	0.162
CD8⁺ T_CM CCR5⁺	12.8 (5.4–25.8)	2.8 (1.9–7.2)	6.3 (3.9–8.7)	3.2 (2.3–8.7)	0.002	0.049	0.037

Only values with significant differences between cell populations are presented.

No differences were found between HIV−HBV+HCV+ and HIV−HBV−HCV+ subjects or HIV−HBV−HCV+ and triple negative subjects. Holm–Bonferroni corrected p < 0.05 is considered statistically significant and is marked in bold.

^{^a}

HIV+ HBV+ HCV+ compared to HIV−HBV+ HCV+.

^{^b}

HIV+ HBV+ HCV+ compared to HIV−HBV−HCV+.

^{^c}

HIV+ HBV+ HCV+ compared to triple negative.

T_N, naive; T_CM, central memory; T_EM, effector memory; T_TEMRA, terminally differentiated cells.