. 2016 Oct 5;12:698–706. doi: 10.1016/j.nicl.2016.09.023

Table 1.

ROI analysis: Significant main and interaction effects of the picture valence (threat, neutral pictures) by group (GAD, PD, SAD, HC) ANOVA.

Region	Lateralization	x	y	z	F	mm³
Main effect: picture valence
Increased activity to threat > neutral pictures
pgACC/aMCC/pMCC	L/R	− 2	0	31	16.15	4920^a
PCC	L/R	− 14	− 39	36	14.69	3112^a
Anterior insula ventral/dorsal	L	− 25	13	− 10	19.19	2843^a
Anterior insula ventral/dorsal	R	28	21	− 6	16.54	3201^a
Amygdala	L	− 19	− 5	− 10	24.75	1560^a
Amygdala	R	16	− 6	− 11	23.35	1872^a
OCC	L	− 39	− 55	− 10	30.43	21302^a
OCC	R	37	− 71	− 6	21.87	16734^a
Thalamus	L	− 13	− 29	0	13.04	2207^a
Thalamus	R	1	− 13	8	12.57	1305^a
FG	L	− 39	− 55	− 11	29.17	6888^a
	R	38	− 47	− 10	24.70	7345^a
	L	− 36	− 12	− 21	13.88	648
vlPFC to dlPFC	L	− 47	29	10	20.53	20896^a
vlPFC to dlPFC	R	41	5	30	23.17	22171^a
dlPFC	R	40	− 2	52	9.49	160
mPFC	R/L	− 3	49	34	14.91	13984^a

Reduced activity to threat > neutral pictures
vlPFC	L	− 23	48	1	11.87	560
vlPFC	R	27	54	7	9.84	976
dlPFC	R	28	14	56	11.38	2600

Interaction effect: picture valence by group
aMCC	L	− 9	28	20	6.00	192^b
pMCC	L	− 14	− 13	43	6.22	184^b
dPCC	R	10	− 42	34	5.29	88^b
daI/FO	L	− 32	15	17	6.14	160^b
posterior dlPFC	L	− 31	27	48	5.22	472^b
vlPFC	L	− 38	33	6	4.92	56

Dissolving the interaction effects (picture valence by group) in ROI analysis in response to threat versus neutral pictures
	aMCC	pMCC	dPCC	daI/FO	posterior dlPFC	vlPFC
GAD vs. SAD	t_[39] = 5.03, p < 0.001	t_[39] = 5.08, p < 0.001	t_[39] = 3.12, p = 0.003	t_[39] = 4.95, p < 0.001	t_[39] = 3.05, p = 0.004	t_[39] = 2.52 p = 0.016
GAD vs. PD	t_[39] = 2.84, p = 0.007	t_[39] = 3.88, p < 0.001	t_[39] = 3.64, p = 0.001	t_[39] = 3.68, p = 0.001	t_[39] = 3.36, p = 0.002	t_[39] = 2.23 p = 0.031
GAD vs. HC	t_[39] = 3.53, p = 0.001	t_[39] = 2.71, p = 0.010	t_[39] = 2.94, p = 0.005	t_[39] = 2.95, p = 0.005	t_[39] = 2.42, p = 0.020	n.s.
SAD vs PD	n.s.	n.s.	n.s.	n.s.	n.s.	n.s.
SAD vs. HC	n.s.	n.s.	n.s.	n.s.	n.s.	t_[40] = 2.79, p = 0.008
PD vs. HC	n.s.	n.s.	n.s.	n.s.	n.s.	t_[40] = 2.52, p = 0.016

Note. ROI, region of interest; ANOVA, analysis of variance; GAD, generalized anxiety disorder; SAD, social anxiety disorder; PD, panic disorder; HC, healthy controls; pgACC, pregenual anterior cingulate cortex; aMCC, anterior mid cingulate cortex; pMCC, posterior mid cingulate cortex; PCC, posterior cingulate cortex; dPCC, dorsal posterior cingulate cortex; OCC, occipital cortex; aI, anterior insula; FG, fusiform gyrus; mPFC, medial prefrontal cortex; vlPFC, ventrolateral prefrontal cortex; dlPFC, dorsolateral prefrontal cortex; daI/FO, dorsal anterior insula/frontal operculum L, left; R, right; x,y,z, Talairach coordinates of maximally activated voxel (activation threshold: p < 0.05 corrected).

Depicted in Fig. 1.

Depicted in Fig. 2.