Table 2. Exome array meta-analysis top 10 variants.

CHR	Variant	rs ID	Position	A1	CLOZUK P-value	CIAC P-value	Meta-analysis P-value	Gene	Location	Function
4	exm387558	rs201099591	7 436 363	A	2.48 × 10−3	1.31 × 10−4	1.10 × 10−6	PSAPL1, SORCS2	Exonic, intronic	Missensea
7	exm622984	rs17139320	63 726 370	G	3.96 × 10−3	2.87 × 10−4	3.70 × 10−6	ZNF679	Exonic	Missensea
8	exm729894	rs201071539	145 003 862	A	2.19 × 10−3	1.69 × 10−3	1.19 × 10−5	PLEC	Exonic	Missensea
19	exm1421170	rs2591594	9 076 728	A	4.66 × 10−3	3.26 × 10−3	4.52 × 10−5	MUC16	Exonic	Missenseb
12	exm988839	rs1546308	21 176 135	C	1.25 × 10−4	0.0679	9.13 × 10−5	SLCO1B7, SLCO1B3	Exonic, intronic	Missensea
1	exm23767	rs12073549	17 720 545	T	1.60 × 10−3	0.0163	9.31 × 10−5	PADI6	Exonic	Synonymous
15	exm1186658	rs117116488	89 390 513	T	2.76 × 10−4	0.0448	9.73 × 10−5	ACAN	Exonic	Missenseb
12	exm981950	rs79149293	8 975 873	G	5.66 × 10−5	0.0967	1.01 × 10−4	A2ML1	Exonic	Missensec
12	exm995289	rs138912646	42 711 606	A	3.94 × 10−5	0.1613	1.79 × 10−4	ZCRB1, PPHLN1	Exonic, intronic	Missensea
12	exm1051374	rs143584336	130 921 539	A	1.22 × 10−4	0.1144	2.12 × 10−4	RIMBP2	Exonic	Missensea

Abbreviations: A1, minor reference allele; CHR, chromosome; CIAC, Clozapine-Induced Agranulocytosis Consortium.

Results are ordered by meta-analysis P-value. Predicted function of non-synonymous variants.

^aBenign.

^bPossibly damaging.

^cProbably damaging. Further details, including minor allele frequencies, are available in Supplementary Data 3.