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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Chem Biol Drug Des. 2016 Jan 17;87(5):794–805. doi: 10.1111/cbdd.12713

Figure 5.

Figure 5

Characterization of AQP1 inhibitors using Xenopus oocyte-swelling assay. Membrane water permeability of Xenopus laevis oocytes injected with distilled water (control) or 25 ng/oocyte human AQP1 cRNA (experimental) is shown. Oocytes were incubated in culture medium, DMSO (solvent used for dissolving the compound) or AQP1 inhibitor dissolved in DMSO as represented in the figure. Membrane water permeability was determined as described in the Methods and Materials section. Each bar represents mean ± SD from 15 oocytes.