. Author manuscript; available in PMC: 2016 Oct 14.

Published in final edited form as: Exp Cell Res. 2014 Oct 16;330(1):212–221. doi: 10.1016/j.yexcr.2014.09.031

Table 2.

Effects of TSA on insulin mRNA levels and various stages of the RSP of GLUTag-INS and EINS, represented as a fold-difference from non-treated GLUTag-INS. Basal secretion results are represented under the proinsulin and insulin secretion column. Average non-treated GLUTag-INS values were mRNA-1.0, intracellular proinsulin-4.2 fmol/105 cells, intracellular insulin-142 fmol/10⁵ cells, basally secreted proinsulin-8.6 fmol/(10⁵ cells·h), and basally secreted insulin-15.3 fmol/(10⁵ cells·h).

			Intracellular Content		Secreted
TSA	Cells	mRNA	Proinsulin	Insulin	Proinsulin	Insulin
(−)	GLUTag-EINS	3.5	1.9	1.1	0.5	0.6
(+)	GLUTag-INS	1.1	2.1	2.6	4.8	2.4
(+)	GLUTag-EINS	23	10.9	3.0	8.0	3.8