Table 3.
Summary of BCG-induced Mycobacterium bovis mycotic aneurysms
Etiology | Localized or disseminated infection by live BCG. Exact mechanism for mycotic aneurysm formation unknown. |
Incidence | Very rare (<< 1%); 32 total reported cases |
Gender ratio | M >> F (31 M, 1 F in reported literature) |
Age predilection | Middle-aged/elderly; Mean age 71 in reported literature |
Location | Aorta (infrarenal > suprarenal) > iliac, femoral > popliteal > carotid > coronary |
Risk factors | Urogenital trauma (i.e. difficult bladder catheterizations, cystitis, recent biopsy or surgery), immunocompromised |
Clinical findings | Fever of unknown origin, unintentional weight loss, abdominal/back pain, abdominal mass, ruptured aneurysm |
Treatment | Long course (6–12 months) anti-mycobacterial antibiotics; Surgical or endovascular repair of aneurysms |
Prognosis | Variable (highly dependent on location of aneurysm, clinical status of patient, co-morbidities) |
Imaging findings | Rapidly enlarging saccular aneurysms in medium-large sized arteries, possible rupture |