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. 2016 Sep 30;38(5):1433–1442. doi: 10.3892/ijmm.2016.2763

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Copyright: © Guo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Rolipram (ROL) attenuates mechanical allodynia and thermal hyperalgesia in rats with bone cancer pain (BCP). (A) The intrathecal administration of ROL at doses of 12.5, 25, 50 and 100 μg/kg significantly attenuated BCP. (B) The paw mechanical withdrawal threshold and (C) the paw withdrawal latency were assessed in different groups of rats at the dose of 50 μg/kg. (D) The effects of ROL at various doses on motor performance were examined by the rotarod test. ^**p<0.01 vs. BCP + vehicle group; ^##p<0.01 vs. sham-operated group (sham). Eight rats were included in each group.