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. 2016 Sep 30;38(5):1433–1442. doi: 10.3892/ijmm.2016.2763

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Copyright: © Guo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Rolipram (ROL) decreases neuron-astrocytic activation in the spinal dorsal horn (SDH). Immunohistochemical analysis of the expression of (A) c-Fos, (B) glial fibrillary acidic protein (GFAP) and (C) ionized calcium binding adapter molecule-1 (IBA-1). Quantification of the relative expression of (D) c-Fos, (E) GFAP and (F) IBA-1 in the SDH. Tissues were collected 14 days following inoculation. Original magnification, ×200. ^**p<0.01; n.s., no significance; BCP, bone cancer pain; Veh, vehicle; Sham, sham-operated.. Four rats were included in each group.