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Rolipram (ROL) decreases spinal pro-inflammatory cytokine levels in rats with bone cancer pain (BCP). The levels of (A) interleukin (IL)-1β, (B) IL-6, (C) tumor necrosis factor (TNF)-α and (D) chemokine (C-C motif) ligand 2 (CCL2) were examined by ELISA. Tissues were collected 14 days following inoculation. **p<0.01; n.s., no significance; Veh, vehicle; Sham, sham-operated. Four rats were included in each group.
