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. 2016 Aug 30;5:e18017. doi: 10.7554/eLife.18017

Table 1.

Numbering of selected residues in Hv1 and Shaker VS domain sequences.

DOI: http://dx.doi.org/10.7554/eLife.18017.002

Residue position Hs Hv1
number
mHv1cc number Ci Hv1 number Shaker number
1.48 V109 V105 V157 I237
1.51 D112 D108 D160 S240
1.52 A113 A109 S161 I241*
1.54 L115 L111 L163 I243
1.55 V116 V112 V164 F244
2.44 I144 F140 L192 T284
2.46 I146 I142 I194 C286
2.47 L147 L143 L195 I287*
2.50 F150 F146 F198 F290
2.51 M151 M147 M199 T291
3.53 V177 I173 V225 A319
3.54 V178 V174 V226 I320
3.58 F182 F178 F230 F324
3.61 D185 D181 D233 L327
3.65 L189 L185 I237 V331
4.40 L198 L194 I248 M356
4.43 L201 L197 L251 L358
4.44 I202 I198 V252 A359
4.46 L204 L200 L254 L361
4.47 R205 R201 R255 R362

*Shaker I241H (I1.52) and I287H (I2.47) confer GSH (Campos et al., 2007).

Functionally substitutes for D1.51 in background of D112V (Morgan et al., 2013).

Ile3.53 was transferred from Ci VSP into mHv1cc chimera (Takeshita et al., 2014).