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. Author manuscript; available in PMC: 2017 Sep 21.
Published in final edited form as: J Am Chem Soc. 2016 Sep 12;138(37):12069–12072. doi: 10.1021/jacs.6b08486

Table 2.

Phosphine-Catalyzed Asymmetric Synthesis of Benzylic Ethers: Scope with Respect to the Aryl Groupa

graphic file with name nihms819660u4.jpg
entry Ar ee (%) yield (%)b
1 graphic file with name nihms819660t1.jpg 96 94
2 95 90
3 96 84
4c graphic file with name nihms819660t2.jpg 88 76
5c 86 86
6c,d graphic file with name nihms819660t3.jpg 88 64
7 graphic file with name nihms819660t4.jpg 94 97
8 graphic file with name nihms819660t5.jpg 92 93
9 graphic file with name nihms819660t6.jpg 92 96
10 graphic file with name nihms819660t7.jpg 92 89
a

All data are the average of two experiments.

b

Yield of purified, isolated product.

c

Catalyst loading: 10% (S)–1.

d

Amount of nucleophile: 2.0 equiv.