Figure 2.

Flowchart for pathway modeling using computational approaches. The bioinformatics methods for pathway modeling starts with the hypothesis of pathway construction which can be derived from experiments or theory. Then computational methods can be performed on the experiment data (e.g. Microarray data, RNASeq data) and knowledge information (e.g. Pathway information, functional annotation) to model the biological pathways. The predicted pathways can be refined by evaluating each model with experiments and hypothesis. (A colour version of this figure is available online at: http://bfg.oxfordjournals.org)