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Particle-cell dynamics in blood flow and their influence on margination. Nanosized carriers, both spherical and rod-like, are more likely to become entrapped in the RBC core, and are unable to effectively marginate to the vascular wall. Larger particles, 1–2µm in size, are pushed toward the cell-free layer, where they are able to interact with the endothelium. Rod-like microparticles may exhibit enhanced margination due to an increased drift force and tumbling motion in flow.
