Table 2.
Appendectomy and Extensive Disease are Independently Associated with a Higher Rate of Colectomy
| Univariable Analysis | Multivariable Analysis* | |||
|---|---|---|---|---|
| OR (95% CL) | P - value | OR (95% CL) | P - value | |
| Appendectomy | 1.65 (1.05 – 2.57) | 0.03 | 1.87 (1.12 – 3.14) | 0.02 |
| Female | 0.81 (0.67 – 0.98) | 0.03 | 0.95 (0.75 – 1.20) | 0.68 |
| Non-White Race | 0.96 (0.76 – 1.21) | 0.73 | 0.99 (0.75 – 1.32) | 0.96 |
| Smoking | ||||
| Never | 1.00 (reference) | 1.00 (reference) | ||
| Former | 1.07 (0.83 -1.37) | 0.61 | 1.44 (1.05 – 1.98) | 0.03 |
| Current | 0.96 (0.67 – 1.35) | 0.80 | 1.01 (0.66 – 1.53) | 0.97 |
| 1st Degree Relative with IBD | 1.26 (0.98 – 1.62) | 0.07 | 1.37 (1.01 – 1.86) | 0.05 |
| Age at Diagnosis (decade) | 0.93 (0.87 – 0.99) | 0.03 | 0.92 (0.85 – 1.01) | 0.85 |
| Disease Location | ||||
| Proctitis | 1.00 (reference) | 1.00 (reference) | ||
| Left-sided | 1.07 (0.61 – 1.90) | 0.81 | 1.04 (0.52 – 2.08) | 0.90 |
| Extensive | 4.28 (2.55 – 7.20) | <0.01 | 4.58 (2.44 – 8.58) | <0.01 |
| EIM | 1.71 (1.37 – 2.13) | <0.01 | 1.73 (1.33 – 2.25) | <0.01 |
| Disease Duration | ||||
| 0 to 5 | 1.00 (reference) | 1.00 (reference) | ||
| 6 to 10 | 0.82 (0.62 – 1.10) | 0.19 | 0.93 (0.68 – 1.27) | 0.63 |
| 11 to 20 | 0.72 (0.55 – 0.94) | 0.02 | 0.74 (0.55 – 0.99) | 0.05 |
| > 20 | 0.57 (0.39 – 0.82) | <0.01 | 0.54 (0.36 – 0.82) | <0.01 |
*
Adjusted for: Appendectomy, sex, race, smoking status, family history of IBD, age at IBD diagnosis, disease location, presence of extra-intestinal manifestations, and disease duration.