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. Author manuscript; available in PMC: 2016 Oct 14.
Published in final edited form as: Annu Rev Virol. 2016 Jul 22;3(1):387–409. doi: 10.1146/annurev-virology-110615-042215

Figure 5.

Figure 5

De-envelopment at the outer nuclear membrane. It is still largely unclear how de-envelopment of herpesvirus capsids is mediated. Viral glycoproteins that are required for viral entry do not play the same role here, suggesting that an unidentified cellular fusion machinery drives the de-envelopment process. Some viral proteins, such as US3 and UL51, may be involved in the process, but their roles are unclear. US3 kinase activity may aid nuclear egress complex lattice disassembly prior or coincident with membrane fusion.