Table 1.

Demographics, laboratory measures, body composition, insulin sensitivity and iron metabolism mediators in men with and without HH. All patients had their testosterone concentrations measured twice at baseline. The concentrations reported in the table for total, free and calculated free testosterone are an average of the two measurements.

	Hypogonadal	Eugonadal	P
Number of subjects	44	50
Age (years)	54.6±7.9	51.5±8.9	0.075
Duration of diabetes (years)	9.4±8.6	10.9±9.8	0.50
BMI (kg/m2)	39.8±7.8	34.0±6.4	<0.001
Testicular size (ml)	17.4±4.7	19.1±5.3	0.19
Laboratory measurements
Total testosterone (nmol/L)	8.8±2.8	16.8±6.4	<0.001
Free testosterone (nmol/L)	0.15±0.04	0.26±0.08	<0.001
Calculated Free testosterone (nmol/L)	0.19±0.04	0.33±0.06	<0.001
SHBG (nmol/L)	26.3±12.8	36.0±23.5	0.01
LH (IU/L)	3.9 [2.4, 5.8]	5.0 [3.6, 6.1]	0.05
FSH (IU/L)	5.3 [3.5, 9.4]	6.9 (4.2, 9.3]	0.34
HbA1c% (mmol/mol)	7.0±1.1 (53±12)	7.1±1.1 (54±12)	0.66
Hematological parameters
Hemoglobin (g/L)	138±13	146±12	0.002
Hematocrit %	41.1±3.9	43.8±3.2	0.001
Prevalence of anemia	20%	10%	0.18
Red blood cell count (million/μL)	4.6±0.4	4.9±0.5	0.001
Mean corpuscular volume (fL)	90.1±5.3	89.3±5.8	0.47
Mean corpuscular hemoglobin (pg/cell)	30.1±2.0	29.9±2.4	0.60
Mean corpuscular hemoglobin concentration (g/L)	334±7	334±10	0.93
Red cell distribution width (%)	14.2±1.2	14.2±1.2	0.81
White blood cells (thousands/μL)	7.5±0.4	6.7±2.0	0.11
Platelets(thousands/μL)	221±61	210±49	0.36
Hepcidin (ng/ml)	197±14	207±16	0.73
Erythropoietin (mU/ml)	21.7±3.9	23.5±4.8	0.41
Transferrin (μg/dl)	261±8	256±9	0.83
Transferrin Saturation (%)	22.1±4.2	23.2±3.7	0.87
Ferritin (μg/ml)	2.11±0.16	2.28±0.16	0.74
Iron (μg/dl)	78±7	85±8	0.28
TIBC (μg/dl)	342±14	317±12	0.31
UIBC (μg/dl)	261±16	229±15	0.54
Ferroportin expression (Arbitrary Units)	0.48±0.08	0.43±0.14	0.62
Transferrin Receptor-2 expression (Arbitrary Units)	0.83±0.17	0.91±0.28	0.45