Table 2.

IC/BPS treatments

Medication	Dosage
Amitriptyline	25–75 mg po qhs
Cimetidine	400 mg po bid
Hydroxyzine	10–50 mg po qhs
Oral pentosan polysulfate (PPS)	100 mg po tid
Intravesical pentosan polysulfate	200 mg PPS mixed with 30 mL sterile buffered NS retained for 30–60 minutes
Cyclosporine A	2–3 mg/kg divided bid
Gabapentin	300–2100 mg po divided tid
Quercetin	500 mg po bid
Intravesical dimethysulfoxide (DMSO)	50 mL solution of 50% DMSO (Rimso-50) for 30–60 minutes, once weekly for six weeks; monthly maintenance prn
Intravesical heparin	20 000–40 000 IU of heparin diluted in 10 mL NS for 30–60 minutes, weekly for 4–6 weeks
Intravesical hyaluronic acid	40 mg/50 mL vial (Cystistat®), weekly instillations for 4–12 treatments, then monthly until symptoms resolve
Intravesical chondroitin sulfate (CS)	20 mL vial of 2.0% CS (Uracyst®), retained 30 minutes, weekly for six weeks, then monthly until symptoms resolve
Intravesical alkalinized lidocaine	200 mg lidocaine, alkalinized with a sequential instillation of 8.4% NaHCO3 solution, to a final volume of 10 mL (Urolieve®, PSD597)
Intravesical oxybutynin	10 mg oxybutynin (crushed tablets) diluted in 500 mL NS instilled until first sensation; weekly for six weeks, then monthly for three months
Hydrodistension (HD)	Therapeutic HD under spinal or general anesthesia, where the bladder is filled with NS by gravity drainage at a pressure of 80 cm H2O to its capacity and distension is maintained for two to no more than 10 minutes; the bladder is drained at the end and capacity is measured
Triamcinolone (steroid) injection for Hunner’s lesions	1 mL vial of triamcinolone (40 mg/mL) diluted in 9 mL NS (total 10mL), to be injected in aliquots of 1 mL
Botulinum toxin A	100U suburothelial injection ± trigone

bid: twice daily; IC/BPS: interstitial cystitis/bladder pain syndrome; NaHCO3: sodium bicarbonate; NS: normal saline; po: orally; qhs: every night at bedtime; tid: three times daily.