Figure 7.

Model for Parental Histone Dynamics Coupled to Repair in UVC-Damaged Chromatin

UVC damage leads to the redistribution of parental histones to the periphery of damaged chromatin regions. This occurs via a decompaction of damaged chromatin, which pushes away the surrounding undamaged chromatin fibers, along with a mobilization of parental histones on chromatin away from damage sites, making room for new histone incorporation. Restoration of the overall chromatin organization proceeds by chromatin re-compaction and sliding back the nucleosomes bearing parental histones. The whole process is tightly coordinated with DNA repair progression through binding and release of the damage sensor DDB2.