Table 2.

Significantly enriched GO categories and pathways by commonly down-regulated genes between DOX-Day2 and DOX-Day6

Components	Gene count	p value	Representative genes
GO term
GO:0006936—muscle contraction	23	3.4E−11	SLC8A1, TCAP, ACTA1, MYL3, PGAM2, MYH7, MYH6, TNNI3, GJA5, EDNRA, DES, TNNT1, MYOM2, ARG2, RYR2, ASPH, KCNH2, SCN5A, KCNQ1, CASQ2, HRC, SGCA, MB
GO:0005856—cytoskeleton	74	1.9E−10	KIF23, PRC1, TTK, AURKA, AURKB, GTSE1, KIF2C, FRMD5, DES, ANK2, LMOD2, MYC, TOP2A, LMOD3, TUBA1B, ASPM, KIF14, CDC6, CDK1, KIF11, ACTA1, KIF15, TPX2, LDB3, NUSAP1, MYH7, MYH6, MCM3, TNNT1
GO:0030017—sarcomere	14	8.5E−07	MYL2, ACTA1, TCAP, MYL3, LDB3, FHL2, MYH7, MYH6, TNNI3, DES, TNNT1, ANK2, DMD, RYR2
GO:0003013—circulatory system process	13	0.00262	MYL2, CORIN, TCAP, MYL3, MYH6, NPR3, ATP1A2, TNNI3, EDNRA, RYR2, KCNH2, SCN5A, KCNQ1
GO:0016529—sarcoplasmic reticulum	5	0.01542	PYGM, SRL, RYR2, CASQ2, HRC
KEGG pathways
hsa04260:Cardiac muscle contraction	11	1.98E−05	SLC8A1, MYL2, MYL3, ATP1B4, COX6A2, RYR2, MYH7, ATP1A2, MYH6, TNNI3, CACNA2D2
hsa05410:Hypertrophic cardiomyopathy (HCM)	11	4.24E−05	SLC8A1, DES, MYL2, MYL3, DMD, RYR2, MYH7, MYH6, TNNI3, CACNA2D2, SGCA
hsa05414:Dilated cardiomyopathy	11	8.42E−05	SLC8A1, DES, MYL2, MYL3, DMD, RYR2, MYH7, MYH6, TNNI3, CACNA2D2, SGCA
hsa00240:Pyrimidine metabolism	8	0.009192	PRIM1, NME4, NME2, NME3, NME1-NME2, POLE2, RRM2, POLA1, TK1
hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC)	7	0.011314	SLC8A1, DES, DMD, RYR2, CACNA2D2, SGCA, CTNNA3
hsa00230:Purine metabolism	10	0.013765	PRIM1, NME4, ADSSL1, NME2, NME3, NME1-NME2, POLE2, PDE1C, RRM2, POLA1, PAICS