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. 2016 Jun 27;31(10):1021–1034. doi: 10.1007/s10654-016-0171-5

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Average maternal alcohol dose and frequency of alcohol consumption in first trimester: summary odds ratios and 95 % confidence intervals for a cleft lip only, b cleft lip with cleft palate, c cleft palate only, and d all clefts. Results were adjusted for maternal age (continuous), smoking in first trimester (yes/no), and study site. The vertical lines represent 95 % confidence intervals. NB = non-binge drinking defined as an average of <=4 drinks/sitting; Binge defined as an average of 5+ drinks/sitting