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Role of XOR in the effects mediated by nitrite. Relative mRNA (A) and protein levels (B) of XOR are presented as fold change of nonactivated control macrophages. Uric acid concentration in macrophage culture medium as a measure of XOR activity is given in µmol/l (C). NO production was measured as DAF-FM fluorescence and is presented as % of the l-NAME treated macrophages. Data are shown as mean±SEM, n=6/group (A,C), n=4/group (B), n=8/group (D), * p<0.05 between indicated groups.
