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. 2016 Sep 15;99(4):903–911. doi: 10.1016/j.ajhg.2016.07.017

Figure 2.

Figure 2

Association of rs10941679 with FGF10 and MRPS30 Expression in Normal Breast Tissues, Breast Tumors, and Breast Cancer Cell Lines

(A and B) FGF10 (A) or MRPS30 (B) expression in normal breast (n = 116) or breast tumors from NBCS dataset (n = 241). SNP genotypes are shown on the x axis and log2-normalized gene expression values on the y axis. p values are presented before and after correction for multiple testing using FDR as implemented in p.adjust function in R. Each box plot shows the median rank normalized gene expression (horizontal line), the first through third quartiles (box), and 1.5× the interquartile range (whiskers).

(C and D) Endogenous FGF10 (Hs00610298_m1) (C) or MRPS30 (Hs00169612_m1) (D) expression measured by qPCR in untreated breast cell lines and normalized to GUSB (4326320E). Error bars denote SEM (n = 3). p values were determined with a two-tailed t test. ∗∗p < 0.01, ∗∗∗p < 0.001.