Table 1.
Associations of the Top SNPs from Each Signal with Overall Breast Cancer Risk and Breast Cancer Stratified by ER Status
| Sig | SNP | Com | Min | MAF∗ | OR Overall 95% CI | p Overall | Conditional p Value | OR ER− | p ER− | OR ER+ | p ER+ |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Europeans | |||||||||||
| 1 | rs10941679 | A | G | 0.27 | 1.12 (1.10–1.14) | 2.55 × 10−26 | 6.55 × 10−24 | 1.04 (1–1.08) | 0.059 | 1.15 (1.13–1.18) | 8.35 × 10−30 |
| 2 | rs6864776 | G | A | 0.23 | 1.04 (1.02–1.06) | 7.84 × 10−4 | 1.44 × 10−12 | 1.10 (1.05–1.14) | 2.5 × 10−5 | 1.02 (0.99–1.05) | 0.08 |
| 3 | rs200229088 | TTG | T | 0.31 | 1.09 (1.07–1.12) | 2.28 × 10−12 | 1.12 × 10−5 | 1.03 (0.99–1.09) | 0.11 | 1.12 (1.09–1.15) | 7.51 × 10−14 |
| Asians | |||||||||||
| 1 | rs10941679 | A | G | 0.50 | 1.09 (1.04–1.15) | 9.12 × 10−4 | 0.0859 | 1.03 (0.95–1.11) | 0.53 | 1.11 (1.04–1.18) | 1.32 × 10−3 |
| 2 | rs6864776 | G | A | 0.32 | 0.94 (0.89–1.00) | 3.47 × 10−2 | 0.8901 | 0.95 (0.87–1.04) | 0.28 | 0.94 (0.89–1.00) | 6.24 × 10−2 |
| 3 | rs200229088 | TTG | T | 0.37 | 1.09 (1.02–1.15) | 6.52 × 10−3 | 0.9149 | 1.04 (0.95–1.14) | 0.43 | 1.08 (1.00–1.16) | 3.65 × 10−2 |
Abbreviations are as follows: Com, common alleles; Min, minor alleles; MAF, minor allele frequency; OR, per-allele odds ratios (OR); 95% CI, 95% confidence intervals and 1 degree of freedom; p, significance levels for overall breast cancer are indicated in European and Asian case-control studies, and separately for ER+ and ER− disease.