Table 2.
Haplotype Analysis across the BCAC Studies
| Haplotypes | rs10941679 Signal 1 | rs6864776 Signal 2 | rs200229088 Signal 3 | Haplotype Frequency | OR | p Value |
|---|---|---|---|---|---|---|
| A | 1 | 1 | 1 | 0.395440 | – | – |
| B | 1 | 1 | 2 | 0.120099 | 1.06 (1.02–1.10) | 1.49 × 10−3 |
| C | 1 | 2 | 1 | 0.199599 | 1.10 (1.06–1.13) | 7.76 × 10−11 |
| D | 1 | 2 | 2 | 0.018665 | 1.15 (1.04–1.27) | 5.03 × 10−3 |
| E | 2 | 1 | 1 | 0.098169 | 1.14 (1.09–1.19) | 1.45 × 10−11 |
| F | 2 | 1 | 2 | 0.154525 | 1.20 (1.16–1.24) | 2.72 × 10−30 |
| G | 2 | 2 | 1 | 0.004248 | 0.91 (0.72–1.15) | 4.15 × 10−1 |
| H | 2 | 2 | 2 | 0.009253 | 1.28 (1.10–1.48) | 1.14 × 10−3 |
Each haplotype was compared to the ancestral haplotype carrying the common alleles of signal 1 SNP rs10941679, signal 2 SNP rs6864776, and signal 3 SNP rs200229088 (haplotype A).