Table 3.

Univariable and multivariable survival models for time to organ support removal and overall survival on day 28

Covariate at study entry	Time to vital organ support removal		Day 28 survival
	HR (95 % CI)	p Value	HR (95 % CI)	p Value
Univariable models
Hydrocortisone vs. placebo	1.35 (0.93–1.92)	0.11	0.82 (0.47–1.43)	0.49
APACHE II score: <25 vs. ≥25	1.46 (0.97–2.18)	0.066	0.39 (0.22–0.69)	0.0011
Lung Injury Score: <2.5 vs. ≥2.5	1.57 (1.08–2.30)	0.019	0.71 (0.40–1.24)	0.23
Vasopressor-dependent shock: absent vs. present	1.63 (1.09–2.45)	0.018	0.46 (0.19–1.07)	0.071
ARDS severity: mild vs. moderate to severe	0.79 (0.54–1.16)	0.23	1.54 (0.81–2.96)	0.19
Number of comorbidities: ≤2 vs. >2	0.95 (0.64–1.40)	0.79	1.25 (0.71–2.19)	0.44
Source of infection: pneumonia vs. extrapulmonary source	1.09 (0.64–1.85)	0.75	0.90 (0.51–1.58)	0.71
Age: ≤65 years vs. >65 years	1.40 (0.97–2.02)	0.071	1.33 (0.76–2.35)	0.32
Diabetes mellitus: no vs. yes	0.95 (0.64–1.40)	0.79	1.66 (0.84–3.28)	0.18
Hyperglycemia: no vs. yes	0.97 (0.66–1.42)	0.8	1.37 (0.67–2.80)	0.45
Multivariable models
Hydrocortisone vs. placebo	1.35 (0.93–1.96)	0.107	0.80 (0.46–1.41)	0.44
APACHE II score: <25 vs. ≥25	Not included in multivariable model		0.42 (0.24–0.75)	0.003
Vasopressor-dependent shock: absent vs. present	1.562 (1.04–2.35)	0.032	0.55 (0.23–1.29)	0.17a
Lung Injury Score: <2.5 vs. ≥2.5	1.633 (1.11–2.4)	0.012	Not included in multivariable model

APACHE II Acute Physiology and Chronic Health Evaluation II, ARDS Acute respiratory distress syndrome

Multivariable survival models for time to survival on day 60 were significant for APACHE II score (HR 0.56, 95 % CI 0.35–0.89; p = 0.015) and Lung Injury Score (HR 0.62, 95 % CI 0.39–0.99; p = 0.045), and they showed a nonsignificant favorable trend for hydrocortisone vs. placebo (HR 0.81, 95 % CI 0.51–1.28; p = 0.37)

^aThis variable was included because it was significant in the day 60 survival model