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. 1992 Dec 15;89(24):11862–11866. doi: 10.1073/pnas.89.24.11862

Long-term transformation of an inhibitory into an excitatory GABAergic synaptic response.

D L Alkon 1, J V Sánchez-Andrés 1, E Ito 1, K Oka 1, T Yoshioka 1, C Collin 1
PMCID: PMC50657  PMID: 1334550

Abstract

For a constant membrane potential, a predominantly inhibitory GABAergic synaptic response is shown to undergo long-term transformation into an excitatory response after pairing of exogenous gamma-aminobutyric acid (GABA) with postsynaptic depolarization or pairing of pre- and postsynaptic stimulation. Current- and voltage-clamp experiments suggest that this synaptic transformation is due to a shift from a net increase of conductance to a net decrease of conductance in response to GABA. GABA-induced elevation of intracellular calcium is prolonged after the same stimulus pairing and may, therefore, contribute to this synaptic transformation via Ca(2+)-activated phosphorylation pathways. This synaptic transformation, which does not follow unpaired stimulus presentations, occurs in a neuronal compartment spatially separated from the soma, which also changes during stimulus pairing.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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