Table 4. Adjusted Changes in Metabolic Variables of Patients With Overweighta.
| Value | Placebo, n = 24 | Low-Dose Cuminum cyminum L. Plus Lime, n = 24 | High-Dose Cuminum cyminum L. Plus Lime, n = 24 | P Valueb |
|---|---|---|---|---|
| FPG, mg/dL | 1.8 ± 4.3 | -6.6 ± 4.1 | -19.2 ± 4.1 | 0.004 |
| Insulin, μIU/mL | -0.4 ± 0.5 | -0.7 ± 0.5 | -1.0 ± 0.5 | 0.75 |
| HOMA-IR | -0.2 ± 0.2 | -0.2 ± 0.2 | -0.5 ± 0.2 | 0.47 |
| HOMA-B | -0.7 ± 2.4 | -0.6 ± 2.3 | 0.6 ± 2.3 | 0.89 |
| QUICKI | 0.003 ± 0.005 | 0.009 ± 0.005 | 0.02 ± 0.005 | 0.06 |
| TG, mg/dL | 9.3 ± 7.4 | 9.3 ± 7.3 | -9.2 ± 7.3 | 0.13 |
| TC, mg/dL | 0.4 ± 5.7 | 8.1 ± 5.7 | -19.3 ± 5.6 | 0.003 |
| LDL-C, mg/dL | -2.1 ± 4.6 | 6.9 ± 4.5 | -12.8 ± 4.5 | 0.01 |
| HDL-C, mg/dL | -0.4 ± 1.4 | -0.8 ± 1.4 | -3.4 ± 1.3 | 0.22 |
| TAC, mM/L | 21.2 ± 19.7 | 69.7 ± 19.7 | 34.7 ± 19.3 | 0.21 |
| GSH, µM/L | 3.9 ± 26.9 | -20.9 ± 26.8 | -43.0 ± 26.8 | 0.48 |
aAll values are expressed as means± SE. Adjusted for baseline values, age and baseline BMI.
bObtained from ANCOVA.
Abbreviations: FPG, fasting plasma glucose; HOMA-IR, homeostasis model of assessment-insulin resistance; HOMA-B, homeostatic model assessment-Beta cell function; QUICKI, quantitative insulin sensitivity check index; LDL-C, low density lipoprotein-cholesterol; HDL-C, high density lipoprotein-cholesterol; TC, total cholesterol; TG, triglycerides; TAC, total antioxidant capacity; GSH, total glutathione.