Table 2.
Summary of Integration Events in HPV16-Positive Responsive and Recurrent Tumors. Locus of integration into the cellular genome are shown on the right side of the of the table. Responsive tumors (top five tumors) are 1733, 1769, 1804, 1971, and 2148. Recurrent tumors (bottom five) are 0732, 0843, 1040, 2049 and 2238, indicated in bold text. (F), (R) = Forward or Reverse viral orientation in relation to the cellular gene.
| Tumor | HPV Site | Cellular | ||||
|---|---|---|---|---|---|---|
| Locus | Gene | Gene Name | Region | Domain | ||
| 1733 | (F)E2 | 2p16 | Intergenic | |||
| 1769 | (F)E2 | 9q21 | Intergenic | |||
| (R)L1 | 16q11.2 | Intergenic | ||||
| (R)L1 | 4q27 | Intergenic | ||||
| 1804 | (R)E1 | 6q16 | Intergenic | |||
| (F)L2 | 10p11.1 | Intergenic | ||||
| (F)E5 | 16q11.2 | Intergenic | ||||
| (F)E2 | 16q11.2 | Intergenic | ||||
| 1971 | (F)E1 | 7p22.3 | Intergenic | |||
| (R)L2 | 4p16.3 | Intergenic | ||||
| (R)L1 | 3q28 | TP63 | Tumor protein p63 | Intron 4 | DNA Binding domain | |
| 2148 | (F)L2 | 7p22 | Intergenic | |||
| 2049 | (R)E1 | 8q11.21 | UBE2V2 | Ubiquitin-conjugating enzyme E2 | Intron 1 | Ubiquitin-Conjugating domain |
| (R)E1 | 14q24.1 | SMOC1 | SPARC related modular calcium binding 1 | Intron 1 | Kazal-like domain | |
| 0843 | (F)L2 | 2q24.3 | SCN2A | Sodium channel, voltage-gated, type II, α subunit | Intron 16 | Helical Transmembrane S6 of repeat II region |
| 2238 | (R)L1 | 1p31.3-p31.2 | NFIA | Nuclear factor I/A | Intron 9 | DNA Binding domain |
| (R)E2 | 15q21.1 | SEMA6D | Semaphorin 6D | Intron 4 | Extracellular Topological Sema domain | |
| 0732 | (R)E2 | 10p11.1 | Intergenic | |||
| (R)L2 | 17p11.2 | TNFRSF13B | Tumor necrosis factor receptor superfamily, 13B | Intron 3 | Extracellular Topological domain | |
| 1040 | (R)L2 | 10p11.1 | Intergenic | |||
| (R)L1 | 16p11.2 | SH2B1 | SH2B Adapter Protein 1 | Intron 3 | Plekstrin Homology domain | |