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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Neuroendocrinology. 2016 Apr 15;104(2):194–208. doi: 10.1159/000446114

Figure 3. GABAergic inhibition of PVN-CRH neurons is diminished in CUMS rats.

Figure 3

(A, B): Original recordings (A) and summary data (B) show that blocking GABAA receptors with gabazine (20 μM) significantly increased firing activity of eGFP-tagged PVN neurons in unstressed rats but decreased firing activity of PVN neurons in CUMS rats (n = 9 neurons in unstressed rats and n = 9 neurons in CUMS rats; * P < 0.05 compared with the basal value of each group, repeated-measures ANOVA with Dunnett's post hoc test). (C, D): Original recordings (C) and summary data (D) show that stimulation of GABAA receptors with muscimol (10 μM) significantly decreased firing activity of eGFP-tagged PVN neurons in unstressed rats but increased firing activity of PVN neurons in CUMS rats (n = 8 neurons in unstressed rats and n = 8 neurons in CUMS rats; * P < 0.05 compared with the basal value of each group, repeated-measures ANOVA with Dunnett's post hoc test).