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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Neuroendocrinology. 2016 Apr 15;104(2):194–208. doi: 10.1159/000446114

Figure 6. Inhibition of NKCC1 normalizes GABA inhibition and the EGABA of PVN-CRH in CUMS rats.

Figure 6

(A, B): Original traces (A) and summary data (B) show the effect of gabazine on the firing activity in PVN-CRH neurons in slices treated with bumetanide in unstressed and CUMS rats (n = 7 neurons in unstressed rats and n = 8 neurons in CUMS rats; * P < 0.05 compared with the basal value of each group, repeated-measures ANOVA with Dunnett's post hoc test). (C): Summary data show the effect of muscimol on the firing activity of PVN-CRH neurons in slices treated with bumetanide in unstressed and CUMS rats (n = 7 neurons in unstressed rats and n = 7 neurons in CUMS rats; * P < 0.05 compared with the basal value of each group, repeated-measures ANOVA with Dunnett's post hoc test). (D, E): Original recordings (D) and summary data (E) show GABA currents recorded at various holding potentials and the EGABA of eGFP-tagged PVN neurons in brain slices treated with vehicle (n = 7 neurons) and bumetanide (n = 6 neurons) in unstressed and CUMS rats.