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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Mol Cancer Res. 2016 Aug 3;14(10):920–927. doi: 10.1158/1541-7786.MCR-16-0161

Figure 1. TLK2 overexpression correlates with chromosomal instability measured by copy number data.

Figure 1

(A) Correlation of the genomic instability index and copy number breakpoint index with TLK2 or TLK1 expression (RNAseq) in 1083 invasive breast cancers based on Spearman’s correlation statistics (copy number and RNAseq data are from TCGA). (B) Genomic Instability Index of TCGA breast tumors from different intrinsic breast cancer subtypes classified based on TLK2 expression. P-values were calculated based on t-test. **P<0.01, ***P<0.001. The samples categorized by PAM-50 subtypes are further classified as TLK2 overexpressing samples and the “rest” samples (see methods for the cut-off of TLK2 overexpression). All intrinsic subtypes show significantly higher genomic instability in samples with TLK2 overexpression.