Table 2.
Associations of the ε2 allele with the risks of diseases of the heart: the role of LDL-C.
| Sex | Family group | Ntotal | Nevent | Model 1 | Model 2 | ||||
|---|---|---|---|---|---|---|---|---|---|
| RR | 95% CI | p-value | RR | 95% CI | p-value | ||||
| Men | LLP | 550 | 267 | 0.75 | 0.55-1.01 | 5.9E-02 | 0.61 | 0.45-0.83 | 1.5E-03 |
| Offspring | 752 | 75 | 0.69 | 0.38-1.25 | 2.2E-01 | 0.54 | 0.31-0.97 | 4.0E-02 | |
| Spouses | 331 | 59 | 1.47 | 0.82-2.62 | 2.0E-01 | 1.32 | 0.73-2.41 | 3.6E-01 | |
| LLP+offspring | 1302 | 342 | 0.72 | 0.55-0.94 | 1.5E-02 | 0.58 | 0.45-0.76 | 7.8E-05 | |
| Women | LLP | 597 | 213 | 0.70 | 0.48-1.03 | 7.2E-02 | 0.59 | 0.40-0.89 | 1.1E-02 |
| Offspring | 1063 | 53 | 0.90 | 0.451.82 | 7.8E-01 | 0.79 | 0.39-1.63 | 5.3E-01 | |
| Spouses | 379 | 45 | 1.23 | 0.60-2.51 | 5.7E-01 | 1.08 | 0.53-2.19 | 8.4E-01 | |
| LLP+offspring | 1660 | 266 | 0.74 | 0.53-1.04 | 7.9E-02 | 0.63 | 0.44-0.89 | 8.7E-03 | |
| M&W | LLP | 1147 | 480 | 0.73 | 0.57-0.92 | 7.5E-03 | 0.60 | 0.47-0.76 | 3.5E-05 |
| M&W | Offspring | 1815 | 128 | 0.78 | 0.50-1.22 | 2.7E-01 | 0.63 | 0.40-1.00 | 4.7E-02 |
| M&W | Spouses | 710 | 104 | 1.31 | 0.84-2.06 | 2.4E-01 | 1.17 | 0.74-1.84 | 5.0E-01 |
| M&W | LLP+offspring | 2962 | 608 | 0.73 | 0.59-0.90 | 2.9E-03 | 0.60 | 0.49-0.74 | 3.1E-06 |
RR is the relative risk evaluated using the Cox proportional hazard regression model.
CI denotes confidence interval.
LLP denotes long living parents.
Model 1: basic adjustment (field center, birth cohorts, as well as sex and family groups, when applicable).
Model 2: basic adjustment + LDL-C.
The results of Model 1 are not the same as in Figure 1A because individuals with missing information on LDL-C (3.5%) were excluded from these analyses.
Ntotal is the sample size; Nevent is the number of events.