Table 4.

Associations of the ε2 allele with the risks of death: the role of endophenotypes.

Sex	Family	Ntotal	Nevent	Model 1			Model 2			Model 3
	Group			RR	95% CI	p-value	RR	95% CI	p-value	RR	95% CI	p-value
M	LLP	556	301	1.21	0.93-1.59	0.163	1.14	0.87-1.48	0.355	1.10	0.84-1.44	0.492
	Off	758	31	0.87	0.39-1.94	0.732	0.95	0.44-2.05	0.895	1.06	0.48-2.31	0.893
	Spouses	333	29	0.29	0.05-1.58	0.153	0.22	0.04-1.19	0.079	0.17	0.03-1.10	0.062
W	LLP	622	318	0.83	0.63-1.11	0.208	0.71	0.52-0.95	0.022	0.70	0.52-0.95	0.021
	Off	1064	29	1.15	0.46-2.89	0.764	1.21	0.49-3.00	0.688	1.19	0.47-2.96	0.716
	Spouses	380	27	1.01	0.39-2.58	0.989	1.00	0.40-2.48	0.994	0.83	0.33-2.08	0.686

RR is the relative risk evaluated using the Cox proportional hazard regression model.

CI denotes confidence interval.

LLP denotes long living parents; “Off” denotes offspring; M denotes men; W denotes women.

Model 1: basic adjustment (field center and birth cohorts);

Model 2: basic adjustment + LDL-C;

Model 3: basic adjustment + LDL-C + diseases of heart + lipid-lowering therapy.

The results of the Model 1 are not the same as in Supplementary Table 5 because individuals with missing information on LDL-C (3.5%) were excluded from these analyses.

N_total is the sample size; N_event is the number of events.