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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Mol Cancer Res. 2016 Jul 18;14(10):976–983. doi: 10.1158/1541-7786.MCR-16-0141

Figure 5.

Figure 5

Colony formation in soft-agar as a measure of anchorage-independent growth in response to 28 day treatment with drug vehicle or 1 or 10 μM AGI-5198. No significant reduction in colony formation was noted in E6/E7/hTERT cells expressing wt IDH1 (A) or in cells transformed by expression of mutant V12H-Ras (B). High-dose AGI-5198 (10 μM) moderately reduced colony formation in mutant IDH1-driven transformed E6/E7 cells (C) and in mutant IDH1-driven transformed E6/E7 cells (post-crisis, D). *P<0.05.