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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Antiviral Res. 2016 Aug 15;134:6–16. doi: 10.1016/j.antiviral.2016.08.014

Table 2.

IC50 values of selected compounds against DENV1-4 proteases and West Nile virus protease.

Compounds A B C D E F G H
DENV 1 Pro IC50 9.65 ±0.32 11.29±0.33 4.06±0.21 10.83±0.37 6.20±1.20 1.15±0.1 0.77±0.05 2.76±0.25
Hill-slope 2.01±0.16 1.55±0.10 1.51±0.18 3.92±0.27 0.71±0.13 1.26±0.10 1.79±0.09 0.92±0.05
DENV 2 Pro IC50 8.22±0.24 10.01±0.28 4.05±0.18 10.45±0.40 4.84 ± 0.60 0.98±0.06 0.56±0.04 2.66±0.19
Hill-Slope 1.79±0.11 2.21±0.18 1.61±0.18 2.75±0.16 1.11±0.16 1.51±0.07 1.60±0.07 0.97±0.04
DENV 3 Pro IC50 9.95±0.45 9.66±0.63 2.94±0.18 11.14±0.38 5.0±1.40 0.91±0.06 0.40±0.03 3.25±0.18
Hill-slope 1.62±0.15 1.33±0.17 0.95±0.09 2.70±0.13 1.03±0.16 1.60±0.08 1.53±0.06 1.05±0.04
DENV 4 Pro IC50 8.95±0.34 12.20±0.47 3.40±0.11 11.04±0.37 5.32±0.60 0.64±0.03 0.13±0.01 3.73±0.14
Hill-slope 2.22±0.21 1.95±0.19 1.53±0.12 3.20±0.16 1.22±0.13 1.45±0.05 0.79±0.03 1.25±0.12
WNV Pro IC50 6.43±0.38 10.06±0.33 2.53±0.10 6.56±0.24 4.31 ± 0.17 0.70±0.04 0.12±0.01 3.24±0.11
Hill-slope 1.63±0.18 1.92±0.18 1.38±0.22 2.64±0.13 1.12±0.11 1.58±0.05 0.88±0.05 1.29±0.03

Values presented here are averages of duplicate experiments and reported with the standard errors of the mean.