Table 3.
Ki, EC50, CC50 and SI index of selected compounds.
| Compound ID | Kinetics of Inhibition | EC50 (μM) | CC50 (μM) | Therapeutic index (TI) | |||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| Ki (μM) | R2 | DENV2 Plaque | DENV2 Replicon | TI-1 | TI-2 | ||
|
| |||||||
| A | 6.9±0.80 | 0.99 | >20 | >20 | >100 | * | * |
| B | 2.7±0.33 | 0.98 | >20 | >20 | 62.44 | * | * |
| C | 1.0±0.15 | 0.97 | 8.97 ± 0.05 | 6.9 ± 0.6 | 76.11 | 8.48 | 11.02 |
| D | 3.6±0.39 | 0.98 | 14.23 ± 0.06 | >20 | >100 | >7.02 | * |
| E | 1.6±0.16 | 0.99 | >20 | 10.4 ± 4.2 | 80.01 | * | 7.69 |
| F | 0.22±0.03 | 0.98 | 2.03 ± 0.1 | 2.29 ± 0.3 | 29.16 | 14.36 | 12.73 |
| G | 0.34±0.05 | 0.98 | 0.084 ± 0.010 | (N.D) | 68.08 | 810.47 | * |
| H | 0.87±0.14 | 0.99 | 8.62 ± 1.32 | (N.D) | >100 | >11.60 | * |
*
Indicates that the TI could not be determined due to lack of inhibitory effect in the tested concentration range (0–20 μM). N.D (not determined)