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Synthesis of santacruzamate A urea analogues. Reagents and conditions: (i) CS2, NaOH, H2O; (ii) 30% H2O2, KOH, H2O; (iii) KNO2, diluted H2SO4, 0 °C to rt; (iv) 68% ethylamine/H2O, 100 °C; (v) phenethylamine, EDC-HCl, TEA, cat. DMAP, CH2Cl2, 0 °C to rt; (vi) 12a or 12b, cat. p-TsOH, NEAT 180 °C, 30 torr; (vii) 13a or 13b, phenethylamine, EDC-HCl, TEA, cat. DMAP, CH2Cl2, 0 °C to rt.
