TABLE 1.
NER factors: homologs, orthologs and functional equivalents
| Human | Rodent | S. cerevisiae | S. pombe | Function | Ref |
|---|---|---|---|---|---|
| XPC | Rad4 | rhp41, rhp42 | Lesion recognition and binding complex | 1 | |
| HR23B | Rad23 | rhp23 | 1 | ||
| Centrin2 | 2 | ||||
| DDB1 | Rad7 | ddb1 | Lesion recognition complex | 1 | |
| DDB2, XPE | Rad16 | rph16 | 1 | ||
| Elongin C | Elc1 | Lesion recognition complex with Rad16 and Rad7 | 1 | ||
| XPA | Rad14 | rhp14 | Lesion recognition, complex stabilization | 1 | |
| XPB | ERCC3 | SSL2, Rad25 | ercc3sp | Helicases; TFIIH factor | 1 |
| XPD | ERCC2 | Rad3 | rad15 | 1 | |
| TTDA | TFIIH factor | 2 | |||
| MMS19L | Mms19 | Stabilizes XPD | 1 | ||
| RPA | RFA | ssb | Stabilizes open single stranded DNA; damage recognition | 1 | |
| XPF | ERCC4 | Rad1 | rad16 | Catalyzes 5’ incision | 1 |
| ERCC1 | ERCC1 | Rad10 | swi10 | 1 | |
| XPG | ERCC5 | Rad2 | rad13 | Catalyzes 3’ incision; stabilizes open complex | 1 |
| DNA pol δ | DNA pol δ | Gap-filling repair synthesis | 1 | ||
| DNA pol ε | DNA pol ε | Gap-filling repair synthesis | 1 | ||
| DNA pol κ | DNA pol κ | 2 | |||
| PCNA | PCNA | Sliding clamp for DNA polymerases | 1 | ||
| RFC | 2 | ||||
| Ligase I | Cdc9 | cdc17 | Ligation | 1 | |
| Ligase III | Ligation complex | 2 | |||
| XRCC1 | |||||
| RNAPII | 2 | ||||
| TFIIS | 2 | ||||
| CSB | ERCC6 | Rad26 | TCR-specific DNA-dependent ATPase | 1 | |
| Rpb9 | Rpb9 | TCR-specific subunit of RNA polymerase II | 1 | ||
| CSA | ERCC8 | Rad28 | TCR-specific ubiquitin ligase | 2 | |
| UVSSA | TCR-specific de-ubiquitinase | 2 | |||
| USP7 | 2 | ||||
| Senataxin | Sen1 | 3 |
References: 1. Tatum and Li 2011; 2. Spivak 2015; 3. Li et al. 2016