Table 1.
The influence of the repeated administration of corticosterone (CORT) on the cystometric parameters in conscious rats
| BP cm H2O |
VV ml |
PVR ml |
ICI s |
BC ml/ cm H2O |
DOI cm H2O/ml |
ANVC cm H2O |
FNVC times/ filling phase |
VTNVC % |
|
|---|---|---|---|---|---|---|---|---|---|
| CON | 2.947 ± 0.160 | 0.842 ± 0.039 | 0.076 ± 0.004 | 902.3 ± 18.71 | 0.189 ± 0.007 | 114.7 ± 4.732 | 2.407 ± 0.081 | 0.861 ± 0.122 | 47.93 ± 1.909 |
| CORT | 5.033 ± 0.359*** | 0.610 ± 0.052** | 0.065 ± 0.004 | 716.0 ± 38.60** | 0.136 ± 0.009*** | 312.9 ± 29.59*** | 5.940 ± 0.334*** | 7.107 ± 0.837*** | 35.07 ± 1.926*** |
| CORT + IMI | 4.480 ± 0.240 | 0.554 ± 0.033 | 0.066 ± 0.005 | 652.3 ± 37.23 | 0.130 ± 0.008 | 319.5 ± 25.39 | 5.207 ± 0.389 | 5.793 ± 0.564 | 36.87 ± 1.393 |
| CORT + FLX | 4.560 ± 0.244 | 0.545 ± 0.036 | 0.053 ± 0.003 | 695.1 ± 41.04 | 0.114 ± 0.008 | 274.6 ± 25.25 | 5.647 ± 0.500 | 5.740 ± 0.513 | 40.67 ± 2.643 |
| CORT + SN 003 | 3.353 ± 0.222^^^ | 0.822 ± 0.045^^ | 0.071 ± 0.006 | 869.9 ± 34.61^ | 0.177 ± 0.008^ | 188.3 ± 15.95^^^ | 4.253 ± 0.349^^ | 3.667 ± 0.341^^^ | 44.13 ± 2.671^ |
| CORT + OXY | 3.240 ± 0.197^^^ | 0.814 ± 0.044^ | 0.087 ± 0.004^ | 911.9 ± 27.27^^ | 0.176 ± 0.008^ | 141.6 ± 5.198^^^ | 3.653 ± 0.223^^^ | 3.253 ± 0.219^^^ | 46.20 ± 1.993^^ |
All results are presented as the means ± SEM (n = 15 rats per group)
The data obtained were assessed by one-way analysis of variance (ANOVA) followed by Tukey’s post hoc test
**p < 0.01 versus CON, ***p < 0.001 versus CON, ^p < 0.05 versus CORT, ^^p < 0.01 versus CORT, ^^^p < 0.001 versus CORT