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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Neuropharmacology. 2016 Aug 11;110(Pt A):431–437. doi: 10.1016/j.neuropharm.2016.08.008

Figure 2. Systemic OX1R blockade significantly reduced compulsive-like alcohol drinking at relatively low doses.

Figure 2

For each animal, data for a given dose were normalized to vehicle exposure in that animal. Overall, 3-mg/kg SB-334867 significantly reduced compulsive-like consumption compared to the 0-mg/kg dose. A one-way ANOVA showed a significant effect across doses on alcohol-quinine consumption (F(4,62)=3.45, p=0.013). Data are shown as mean±SEM. *: p<0.05 compared to 0-mg/kg.