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. 2016 Oct 17;10:232. doi: 10.3389/fncel.2016.00232

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Copyright © 2016 Hong, Tian, Yuan, Qi, Li, Du, Chen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of the Transient receptor potential vanilloid 4 (TRPV4) agonist GSK1016790A on methane dicarboxylic aldehyde (MDA) and nitric oxide (NO) content. (A,B) The MDA content in the hippocampus was increased in a dose-dependent manner by the application of the TRPV4 agonist GSK1016790A (0.1–5 μM/mouse), and the EC₅₀ and n values of the dose-response curve were 0.63 ± 0.14 μM/mouse and 1.40, respectively. (C,D) The NO content in the hippocampus was increased by injection of GSK1016790A (0.1–5 μM/mouse) in a dose-dependent manner, and the EC₅₀ and n values of the dose-response curve were 0.69 ± 0.04 μM/mouse and 1.33, respectively. **P < 0.01 vs. control.