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. 2016 Oct 17;10:232. doi: 10.3389/fncel.2016.00232

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Copyright © 2016 Hong, Tian, Yuan, Qi, Li, Du, Chen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of GSK1016790A on the antioxidant enzyme activity and neuronal nitric oxide synthase (nNOS) protein level and activity. (A) The activities of catalase (CAT) and glutathione peroxidase (GSH-Px) were reduced by GSK1016790A, whereas superoxide dismutase (SOD) activity was unaffected. (B,C) The protein level (B) and activity (C) of nNOS were increased by GSK1016790A. (D) The NO content in the hippocampus was increased by injection of GSK1016790A, which was significantly blocked by the nNOS inhibitor ARL-17477. *P < 0.05 and **P < 0.01 vs. control, ^##P < 0.01 vs. GSK1016790A.